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Human factors is the study of the relationships between people and their activities through the systemic application of the human sciences, integrated within the framework of system engineering. Within the context of aviation, that study includes the interactions among aviation personnel, their environments, and equipment.
Fatigue is a feeling of weariness, tiredness, or lack of energy and is characterized by increased discomfort with lessened capacity for work, reduced efficiency of accomplishment, loss of power or capacity to respond to stimulation. Fatigue must be managed by aviation departments to include it pilots, flight attendants, and maintenance personnel, among others.
Crew Resource Management (CRM) is the incorporation of team management concepts in flight operations.